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Table 4 Baseline values of laboratory parameters

From: Comparative effect of dipeptidyl-peptidase 4 inhibitors on laboratory parameters in patients with diabetes mellitus

Laboratory parametersSitagliptinVildagliptinTeneligliptinAlogliptinLinagliptinp-value
mean (95%CI)mean (95%CI)mean (95%CI)mean (95%CI)mean (95%CI)
HbA1c (%)7.8 (7.7, 7.9)7.8 (7.6, 7.9)7.8 (7.7, 8)7.4 (7.2, 7.6)7.4 (7.3, 7.6)<.0001*
Creatinine (mg/dL)0.8 (0.77, 0.82)0.89 (0.85, 0.93)0.94 (0.9, 0.98)0.82 (0.78, 0.87)1.04 (0.99, 1.09)<.0001*
eGFR (mL/min/1.73m2)74 (72.6, 75.5)70.3 (67.6, 73.1)66.3 (63.7, 68.9)72.5 (69.7, 75.3)61.8 (58.6, 65)<.0001*
HDL (mg/dL)51.3 (50.3, 52.3)47.3 (45.4, 49.1)50.1 (48.3, 52)47.5 (45.6, 49.5)48.9 (46.7, 51.1)0.0002*
TC (mg/dL)192.3 (189.6, 194.9)188.7 (183.7, 193.7)190.1 (185.2, 194.9)188 (182.6, 193.4)189.3 (183.5, 195.1)0.5242
TG (mg/dL)145 (139.1, 151)160.3 (148.9, 171.7)151.3 (140.5, 162)155 (143.3, 166.6)146.2 (133.2, 159.2)0.1483
AST (U/L)27.8 (26.5, 29.1)30.3 (27.9, 32.7)29.8 (27.5, 32.2)29.9 (27.4, 32.4)24.7 (21.9, 27.5)0.0124*
ALT (U/L)30.4 (28.7, 32.1)32.3 (29.1, 35.6)30.2 (27.1, 33.3)34.7 (31.4, 38.1)26.2 (22.4, 29.9)0.0157*
  1. *p < 0.05 (among five DPP-4 inhibitors)
  2. HbA1c hemoglobin A1c, eGFR estimated glomerular filtration rate, HDL high density lipoprotein, TC total cholesterol, TG triglyceride, AST aspartate aminotransferase, ALT alanine aminotransferase, CI confidence interval