Skip to main content
Fig. 6 | BMC Pharmacology and Toxicology

Fig. 6

From: Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells

Fig. 6

Regulation of PI3K/AKT signaling pathway mediated by CPT via GPER in SKBR-3 cells. a The expression of cyclin A, cyclin B, cyclin D, CDK2, PI3K and p-AKT following G-1, G-15 treating together with 5 μM CPT. b The expression of cyclin A, cyclin B, cyclin D, CDK2 and p-AKT following LY294002 treating together with 5 μM CPT. c Effect of CPT treatment for 24 h on PI3K expression by using immunofluorescence assay. Nuclei were counterstained with DAPI (blue). (magnification, × 200, Scale bar represents 10 μm). d The mean fluorescence intensity of PI3K by IF assay was analyzed using Image J software. The results are means of three independent replicates ± S.D. **P < 0.01 or *P < 0.05 vs control group, P < 0.01 vs 5 μM CPT treating group were considered as statistically significant

Back to article page