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Fig. 1 | BMC Pharmacology and Toxicology

Fig. 1

From: Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure

Fig. 1

DOX AUC (a) and cmax (b) across the age range from 0 to 18 years. Typical AUC and cmax values were simulated for children on the 50th percentile of body height and weight for three selected treatment regimens. Underlying DOX doses were adjusted as specified by the respective regimen. NB Registry 2016 N4 (standard dose: 15 mg·m− 2, 0.5 h): reduction to 100% of the body weight-based dose in children < 12 months or < 10 kg; CWS-SoTiSaR (20 mg·m− 2, 3 h): reduction to 67% of the body weight-based dose in children < 6 months and reduction to 100% of the body weight-based dose in children ≥6 months but ≤10 kg; AIEOP-BFM ALL 2017 (30 mg·m− 2, 1 h): reduction to 67% of the BSA-based dose in children < 6 months and reduction to 75% of the BSA-based dose in children 6–12 months. The grey boxes mark the areas of the curve where doses were reduced. For a child on the 50th percentile of body height and weight the threshold for dose reduction is reached at an age of 14 months exceeding a body weight of 10 kg (NB Registry 2016 N4, CWS-SoTiSaR) or 12 months (AIEOP-BFM ALL 2017), respectively

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