Fig. 3

Comparison of observed AUC from 94 patients from the EPOC-MS-001-Doxo trial and dose-adjusted AUC. Adjusted DOX doses were derived from a model-based dose calculation rule. AUC values were calculated based on the post-hoc clearance estimates taken from the NONMEM analysis and normalised to the target AUC of a typical 18-year-old boy. The dashed red line indicates the target AUC of 100% and dotted red lines indicate a range of 80–125%