Table 1 Key aspects that need to be considered for clinical implementation of model-based dosing recommendations

1

Development and implementation of miniaturised bedside analytics in order to minimise pre-analytical variability and facilitate drug monitoring

2

External validation of pharmacokinetic models and, if appropriate, further refinement in order to assess the predictive power and decrease the uncertainties of model predictions

3

Development of optimised limited sampling strategies to keep the burden of blood sampling for children at a minimum

4

Clinical validation of model-based dosing recommendations in a prospectively designed clinical trial