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Fig. 2 | BMC Pharmacology and Toxicology

Fig. 2

From: 18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice

Fig. 2

GA induced apoptosis in HaCaT keratinocytes. (A) HaCaT keratinocytes were seeded into 6-well plates and treated with GA (0 for control, 20, 40 and 80 μM) for 24 h. Cells were harvested and stained with PI and annexin V-FITC. Cell apoptosis was analyzed by flow cytometry. **P < 0.01. ***P < 0.001. (B) HaCaT keratinocytes were treated with GA (0 for control, 40 and 80 μM) for 24 h. Cells were harvested and lysed. Caspase 9 and 3 activities were determined using caspase activity assay kits. **P < 0.01

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