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Table 1 Characteristics of studies included for systematic review and meta-analysis

From: Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis

Author & year Country Study Design & population Study period No of cases (% of Males) No ofcontrols (% of Males) Method of AF exposure assessment Unadjusted OR (95%CI) Adjusted OR (95%CI) Adjusted variables Result of critical appraisal
Wang, 2018 [22] China Hospital based case-control 2008–2012 384 (75.3) 851 (75.7) AF-albumin adduct 7.74 (5.51–10.87) a a Low risk
Chu, 2017 [12] Taiwan Community-based nested case-control 1991–2004 232 (a) 577 (a) AF-albumin adduct 2.29 (1.44–3.64) 2.45 (1.51–3.98) Age, gender, cigarette smoking, alcohol drinking, ALT Low risk
Anitha, 2014 [21] India Hospital based case-control 2009–2010 130 (a) 108 (a) AF-albumin adduct 3.59 (1.56–8.23) a a Low risk
249ser TP53 mutation 3.46 (0.72–16.7)
Kuniholm, 2008 [20] Gambia Hospital based case-control 1997–2001 97 (62.9) 397 (71) 249ser TP53 mutation 3.9 (1.8–8.4) 3.8 (1.5–9.6) Age, gender, recruitment site & date, socioeconomic status, alcohol, tobacco, HBV, HCV Low risk
Ground nut intake 2.6 (1.2–5.8) 2.8 (1.1–7.7)
Kirk, 2005 [19] Gambia Hospital based case-control 1997–2001 98 (65.3) 348 (69.8) 249ser TP53 mutation 5.06 (2.28–11.22) 4.83 (1.71–13.7) Age, gender, recruitment date & site, ethnicity, alcohol, socioeconomic status, HBV & HCV status Low risk
Ground nut intake 0.8546 (0.53–1.37) 1.79 (1.04–3.08)
  1. Abbreviations: AF Aflatoxin, ALT Alanine transaminase, HBV Hepatitis B virus, HCV Hepatitis C virus
  2. aNot reported