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Table 2 Subgroup analyses of AF exposure and risk of liver cirrhosis using unadjusted ORs

From: Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis

Subgroup Studies, N OR (95% CI) p value Tests for heterogeneity
Q p I2
All studies 8 3.35 (2.74,4.10) 0.000 59.58 0.000 88.3%
Study design
 Case-control studies 7 3.67 (2.93,4.59) 0.000 56.38 0.000 89.4%
 Nested case-control studies 1 2.29 (1.44,3.64) 0.000 0.00
Method of AF exposure assessment
 Serum AF-albumin adduct level 3 4.89 (3.77, 6.35) 0.000 17.83 0.000 88.8%
 249ser TP53mutation 3 4.3 (2.55,7.26) 0.000 0.30 0.863 0.0%
 Groundnut consumption 2 1.15 (0.76,1.72) 0.51 5.68 0.017 82.4%
Geographic location
 Asia 4 4.85 (3.75,6.26) 0.000 18.01 0.000 83.3%
 Africa 4 1.84 (1.32,2.55) 0.000 20.75 0.000 85.5%
  1. AF Aflatoxin, OR Odds ratio, CI Confidence interval