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Table 1 Teicoplanin dosing regimen according to renal function

From: Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days

Conventional high loading dose regimen Enhanced high loading dose regimen
eGFR (ml/min /1.73 m2) The total dose for the initial 3 days Maintenance dose after day 3 eGFR (ml/min /1.73 m2) The total dose for the initial 3 day Maintenance dose after day 3
1st day 2nd day 3rd day Total 1st day 2nd day 3rd day Total
≥60 10 mg/kg twice daily 10 mg/kg twice daily 10 mg/kg once daily 50 mg/kg 6.7 mg/kg once daily ≥60 12 mg/kg twice daily 12 mg/kg twice daily 12 mg/kg once daily 60 mg/kg 6.7 mg/kg once daily
40–60 10 mg/kg twice daily 10 mg/kg once daily 10 mg/kg once daily 40 mg/kg 3.3 mg/kg once daily 30–60 12 mg/kg twice daily 12 mg/kg once daily 12 mg/kg once daily 48 mg/kg 5.0 mg/kg once daily
< 40 10 mg/kg twice daily 6.7 mg/kg once daily 6.7 mg/kg once daily 33.4 mg/kg 5.0 mg/kg every 2 days < 30 12 mg/kg twice daily 12 mg/kg once daily 6.7 mg/kg once daily 42.7 mg/kg 6.7 mg/kg every 2 days
  1. eGFR estimate glomerular filtration rate