Table 3 Teicoplanin initial trough concentration (Cmin) in patients receiving a conventional or enhanced high loading dose regimen
Initial Cmin (μg/mL) | Conventional high loading dose regimen (n = 363) | Enhanced high loading dose regimen (n = 149) | P-value |
|---|---|---|---|
Median (interquartile range) | 18.3 (15.1–22.8) | 24.9 (20.8–28.3) | < 0.001 |
No. of patient according to the Cmin categories (%) | |||
< 20 | 213 (58.7%) | 32 (21.5%) | < 0.001 |
20–40 | 149 (41.0%) | 112 (75.2%) | < 0.001 |
≥ 40 | 1 (0.3%) | 5 (3.4%) | 0.009 |