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Table 3 Teicoplanin initial trough concentration (Cmin) in patients receiving a conventional or enhanced high loading dose regimen

From: Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days

Initial Cmin (μg/mL) Conventional high loading dose regimen (n = 363) Enhanced high loading dose regimen (n = 149) P-value
Median (interquartile range) 18.3 (15.1–22.8) 24.9 (20.8–28.3) < 0.001
No. of patient according to the Cmin categories (%)
 < 20 213 (58.7%) 32 (21.5%) < 0.001
 20–40 149 (41.0%) 112 (75.2%) < 0.001
 ≥ 40 1 (0.3%) 5 (3.4%) 0.009