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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis

Fig. 5

In vivo downregulation of glioma-induced angiogenesis; angiogenesis assay. S.c. tumors were implanted in athymic nude mice and were removed and photographed after30 days. Application of naringin (120 mg/kg/day) or with saline alone was done every day until the6animals were6sacrificed. a Quantification of new vessel development by assessment of hemoglobin in cancers as mentioned in Material and methods. b An illustration of s.c.gliomas was presented. c IHC staining of CD31 shows that naringin prevented glioblastoma cancer angiogenesis. d MRNA6expression of6CD105 and CD31 in s.c. tumors. ANOVA was performed using the mean fold change compared with control. **P value< 0.01

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