Table 5 Doses calculated for children of different ages by using empirical formulas of pediatric dose calculation
Pediatric dose calculation methods | PK-Sim Dosea (mg) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Pediatric Population | Young’s rule | Clark’s rule | Weight (mg/kg)-based | BSA-based | |||||
Age (years) | Dose (mg) | Weight (pound) | Dose (mg) | Weight (kg) | Dose (mg) | BSA (m2) | Dose (mg) | ||
Infants to toddler | 1 | 1.53 | 22 | 2.93 | 10 | 2.85 | 0.43 | 4.73 | 1.0 to 2.5 |
Preschool | 5 | 5.88 | 37 | 5 | 17 | 5 | 0.78 | 8.5 | 1.5 to 5 |
School age | 12 | 10 | 88 | 12 | 40 | 11 | 1.25 | 13 | 1.5 to 5 |
Adolescent | 17 | 12 | 132 | 18 | 60 | 17 | 1.58 | 17 | 2.5 to 10 |