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Table 5 Doses calculated for children of different ages by using empirical formulas of pediatric dose calculation

From: Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

  Pediatric dose calculation methods PK-Sim Dosea
(mg)
Pediatric Population Young’s rule Clark’s rule Weight (mg/kg)-based BSA-based
Age (years) Dose (mg) Weight (pound) Dose (mg) Weight (kg) Dose (mg) BSA
(m2)
Dose
(mg)
Infants to toddler 1 1.53 22 2.93 10 2.85 0.43 4.73 1.0 to 2.5
Preschool 5 5.88 37 5 17 5 0.78 8.5 1.5 to 5
School age 12 10 88 12 40 11 1.25 13 1.5 to 5
Adolescent 17 12 132 18 60 17 1.58 17 2.5 to 10
  1. aSame doses were calculated for male and female children