Fig. 4
From: Adipocyte-conditioned medium induces resistance of breast cancer cells to lapatinib
Proximity of adipose tissue protects tumors from the lapatinib-induced cytotoxicity in vivo. Tumor growth of BT-474 breast tumors in mice treated with 135 mg/kg of lapatinib daily were measured in four groups of five SCID mice. The animals of two groups were implanted with human adipose tissue (adip) 1 week prior to tumor xenografts. Animals were either treated with lapatinib (lapa) or not treated (nt)