Table 3 Final model parameters describing joint fixed plasma and hair pharmacokinetics of atazanavir

k₁₂ (litres hour^− 1)

0.44 fixed

0.44 fixed

0.45 fixed

0.44 fixed

CL/F (litres hour⁻¹)

10 fixed

10 fixed

1.04 (99)

0.97 (0.50–1.98)

V_c (litres)

63.4 fixed

63.4 fixed

0.50 fixed

0.50 fixed

F_rac

0.16 (16)

0.15 (0.06 to 0.26)

V_h (litres)

1 fixed

1 fixed

Occasion (Follow-up)_ F_rac

*

*

Occasion (Enrolment)_ F_rac

−0.30 (23)

−0.27 (−0.50 to −0.07)

Adherence score_ F_rac

0.02 (18)

0.015 (0.004 to 0.017)

Body Mass Index-for-age (Normal)_ F_rac

*

*

Body Mass Index-for-age (Thin)_ F_rac

0.54 (22)

0.49 (0.06 to 0.74)

Body Mass Index-for-age (Overweight)_ F_rac

−0.21 (121)

− 0.15 (− 0.26 to − 0.05)

Guardian (Grandparent)_ F_rac

*

*

Guardian (Parent)_ F_rac

0.53 (56)

0.55 (0.03 to 2.58)

Guardian (Uncle/Aunt)_ F_rac

0.12 (177)

0.17 (0.05 to 1.60)

Guardian (Sibling)_ F_rac

−0.54 (35)

−0.60 (− 0.92 to − 0.27)

ɛADD

0.30 (1)

0.29 (0.14 to 0.44)

ɛPROP

0.50 (2)

0.50 (0.39 to 0.61)

σ

1

1