Skip to main content

Table 1 Pharmacokinetic parameters after single administration of Mangiferin calcium salt (MCS) and mangiferin in rats (n = 6)

From: Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease

Parameters Mangiferin calcium salt (MCS) (Mean ± SD) Mangiferin (Mean ± SD)
60 mg/kg 240 mg/kg 960 mg/kg 60 mg/kg 240 mg/kg 960 mg/kg
AUC(0-t)(μg/L·h) 6988.35 ± 1537.44 28,126.50 ± 6750.48* 111,771.00 ± 32,413.59 2200.00 ± 462.89 9187.50 ± 2021.15 37,077.50 ± 11,494.23
AUC(0-∞)(μg/L·h) 7714.49 ± 2005.77 30,981.65 ± 8674.40* 123,314.62 ± 38,227.53 2366.16 ± 567.88 9723.18 ± 2430.80 39,101.95 ± 12,121.60
MRT(0-t)(h) 7.28 ± 1.67 7.27 ± 0.96 7.28 ± 0.98 6.90 ± 1.45 6.89 ± 1.58 6.94 ± 1.87
MRT(0-∞)(h) 9.73 ± 0.98 9.65 ± 0.77 9.71 ± 1.94 8.69 ± 2.17 8.25 ± 2.47 8.21 ± 1.89
T1/2(kα)(h) 1.59 ± 0.13 1.60 ± 0.19 1.57 ± 0.20 1.66 ± 0.22 1.70 ± 0.19 1.72 ± 0.24
T1/2(ke)(h) 3.27 ± 0.52 3.34 ± 0.47 3.36 ± 0.47 3.15 ± 0.41 3.29 ± 0.46 3.30 ± 0.46
Tmax(h) 3.11 ± 0.25 2.99 ± 0.21* 3.06 ± 0.12 4.11 ± 0.33 4.02 ± 0.28 3.97 ± 0.36
Cmax(μg/ml) 0.86 ± 0.21 3.42 ± 0.65* 13.73 ± 3.57 0.28 ± 0.04 1.18 ± 0.28 4.73 ± 1.37
V/F(c) (L/kg) 43.50 ± 8.27 45.11 ± 13.98* 45.54 ± 14.12 134.17 ± 41.59 142.41 ± 41.30 133.34 ± 34.67
CL/F(S)(L/kg·h) 9.23 ± 1.57 9.36 ± 2.53* 9.40 ± 2.54 29.55 ± 7.68 30.05 ± 8.71 28.00 ± 7.12
  1. Compared with mangiferin dosage of 240 mg/kg group, *p < 0.05