|
Parameters
|
Mangiferin calcium salt (MCS) (Mean ± SD)
|
Mangiferin (Mean ± SD)
|
|---|
|
60 mg/kg
|
240 mg/kg
|
960 mg/kg
|
60 mg/kg
|
240 mg/kg
|
960 mg/kg
|
|---|
|
AUC(0-t)(μg/L·h)
|
6988.35 ± 1537.44
|
28,126.50 ± 6750.48*
|
111,771.00 ± 32,413.59
|
2200.00 ± 462.89
|
9187.50 ± 2021.15
|
37,077.50 ± 11,494.23
|
|
AUC(0-∞)(μg/L·h)
|
7714.49 ± 2005.77
|
30,981.65 ± 8674.40*
|
123,314.62 ± 38,227.53
|
2366.16 ± 567.88
|
9723.18 ± 2430.80
|
39,101.95 ± 12,121.60
|
|
MRT(0-t)(h)
|
7.28 ± 1.67
|
7.27 ± 0.96
|
7.28 ± 0.98
|
6.90 ± 1.45
|
6.89 ± 1.58
|
6.94 ± 1.87
|
|
MRT(0-∞)(h)
|
9.73 ± 0.98
|
9.65 ± 0.77
|
9.71 ± 1.94
|
8.69 ± 2.17
|
8.25 ± 2.47
|
8.21 ± 1.89
|
|
T1/2(kα)(h)
|
1.59 ± 0.13
|
1.60 ± 0.19
|
1.57 ± 0.20
|
1.66 ± 0.22
|
1.70 ± 0.19
|
1.72 ± 0.24
|
|
T1/2(ke)(h)
|
3.27 ± 0.52
|
3.34 ± 0.47
|
3.36 ± 0.47
|
3.15 ± 0.41
|
3.29 ± 0.46
|
3.30 ± 0.46
|
|
Tmax(h)
|
3.11 ± 0.25
|
2.99 ± 0.21*
|
3.06 ± 0.12
|
4.11 ± 0.33
|
4.02 ± 0.28
|
3.97 ± 0.36
|
|
Cmax(μg/ml)
|
0.86 ± 0.21
|
3.42 ± 0.65*
|
13.73 ± 3.57
|
0.28 ± 0.04
|
1.18 ± 0.28
|
4.73 ± 1.37
|
|
V/F(c) (L/kg)
|
43.50 ± 8.27
|
45.11 ± 13.98*
|
45.54 ± 14.12
|
134.17 ± 41.59
|
142.41 ± 41.30
|
133.34 ± 34.67
|
|
CL/F(S)(L/kg·h)
|
9.23 ± 1.57
|
9.36 ± 2.53*
|
9.40 ± 2.54
|
29.55 ± 7.68
|
30.05 ± 8.71
|
28.00 ± 7.12
|
- Compared with mangiferin dosage of 240 mg/kg group, *p < 0.05
