Table 1 Pharmacokinetic parameters after single administration of Mangiferin calcium salt (MCS) and mangiferin in rats (n = 6)
Parameters | Mangiferin calcium salt (MCS) (Mean ± SD) | Mangiferin (Mean ± SD) | ||||
|---|---|---|---|---|---|---|
60 mg/kg | 240 mg/kg | 960 mg/kg | 60 mg/kg | 240 mg/kg | 960 mg/kg | |
AUC(0-t)(μg/L·h) | 6988.35 ± 1537.44 | 28,126.50 ± 6750.48* | 111,771.00 ± 32,413.59 | 2200.00 ± 462.89 | 9187.50 ± 2021.15 | 37,077.50 ± 11,494.23 |
AUC(0-∞)(μg/L·h) | 7714.49 ± 2005.77 | 30,981.65 ± 8674.40* | 123,314.62 ± 38,227.53 | 2366.16 ± 567.88 | 9723.18 ± 2430.80 | 39,101.95 ± 12,121.60 |
MRT(0-t)(h) | 7.28 ± 1.67 | 7.27 ± 0.96 | 7.28 ± 0.98 | 6.90 ± 1.45 | 6.89 ± 1.58 | 6.94 ± 1.87 |
MRT(0-∞)(h) | 9.73 ± 0.98 | 9.65 ± 0.77 | 9.71 ± 1.94 | 8.69 ± 2.17 | 8.25 ± 2.47 | 8.21 ± 1.89 |
T1/2(kα)(h) | 1.59 ± 0.13 | 1.60 ± 0.19 | 1.57 ± 0.20 | 1.66 ± 0.22 | 1.70 ± 0.19 | 1.72 ± 0.24 |
T1/2(ke)(h) | 3.27 ± 0.52 | 3.34 ± 0.47 | 3.36 ± 0.47 | 3.15 ± 0.41 | 3.29 ± 0.46 | 3.30 ± 0.46 |
Tmax(h) | 3.11 ± 0.25 | 2.99 ± 0.21* | 3.06 ± 0.12 | 4.11 ± 0.33 | 4.02 ± 0.28 | 3.97 ± 0.36 |
Cmax(μg/ml) | 0.86 ± 0.21 | 3.42 ± 0.65* | 13.73 ± 3.57 | 0.28 ± 0.04 | 1.18 ± 0.28 | 4.73 ± 1.37 |
V/F(c) (L/kg) | 43.50 ± 8.27 | 45.11 ± 13.98* | 45.54 ± 14.12 | 134.17 ± 41.59 | 142.41 ± 41.30 | 133.34 ± 34.67 |
CL/F(S)(L/kg·h) | 9.23 ± 1.57 | 9.36 ± 2.53* | 9.40 ± 2.54 | 29.55 ± 7.68 | 30.05 ± 8.71 | 28.00 ± 7.12 |