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Table 2 Pharmacokinetic parameters after multiple administration of Mangiferin calcium salt (MCS) and mangiferin in rats (n = 6)

From: Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease

Parameters Mangiferin calcium salt (MCS) Mangiferin
240 mg/kg (Mean ± SD)
AUC(0-t)(μg/L·h) 27,871.50 ± 9197.60* 9075.00 ± 2631.75
AUC(0-∞)(μg/L·h) 30,789.48 ± 11,084.21* 9729.04 ± 2724.13
MRT(0-t)(h) 7.31 ± 1.82 6.93 ± 0.97
MRT(0-∞)(h) 9.77 ± 2.40 8.63 ± 1.05
T1/2(kα)(h) 0.77 ± 0.08 0.84 ± 0.11
T1/2(ke)(h) 5.54 ± 0.72 4.92 ± 0.63
Tmax(h) 3.02 ± 0.09* 4.05 ± 0.36
Cssmin(μg/ml) 0.12 ± 0.02* 0.03 ± 0.01
Cmax(μg/ml) 3.42 ± 1.19* 1.16 ± 0.20
Cavg(μg/ml) 1.16 ± 0.09* 0.38 ± 0.03
V/F(c) (L/kg) 75.73 ± 18.93* 215.53 ± 40.95
CL/F(S)(L/kg·h) 9.48 ± 1.52* 30.36 ± 8.50
FI(%) 2.84 ± 0.19 2.97 ± 0.21
  1. Compared with mangiferin group, *p < 0.05