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Table 2 Pharmacokinetic parameters after multiple administration of Mangiferin calcium salt (MCS) and mangiferin in rats (n = 6)

From: Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease

Parameters

Mangiferin calcium salt (MCS)

Mangiferin

240 mg/kg (Mean ± SD)

AUC(0-t)(μg/L·h)

27,871.50 ± 9197.60*

9075.00 ± 2631.75

AUC(0-∞)(μg/L·h)

30,789.48 ± 11,084.21*

9729.04 ± 2724.13

MRT(0-t)(h)

7.31 ± 1.82

6.93 ± 0.97

MRT(0-∞)(h)

9.77 ± 2.40

8.63 ± 1.05

T1/2(kα)(h)

0.77 ± 0.08

0.84 ± 0.11

T1/2(ke)(h)

5.54 ± 0.72

4.92 ± 0.63

Tmax(h)

3.02 ± 0.09*

4.05 ± 0.36

Cssmin(μg/ml)

0.12 ± 0.02*

0.03 ± 0.01

Cmax(μg/ml)

3.42 ± 1.19*

1.16 ± 0.20

Cavg(μg/ml)

1.16 ± 0.09*

0.38 ± 0.03

V/F(c) (L/kg)

75.73 ± 18.93*

215.53 ± 40.95

CL/F(S)(L/kg·h)

9.48 ± 1.52*

30.36 ± 8.50

FI(%)

2.84 ± 0.19

2.97 ± 0.21

  1. Compared with mangiferin group, *p < 0.05
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BMC Pharmacology and Toxicology

ISSN: 2050-6511

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