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Table 5 Associated factors for potential DDIs

From: Prevalence of potential drug-drug interactions and associated factors among outpatients and inpatients in Ethiopian hospitals: a systematic review and meta-analysis of observational studies

Factors Description
No of prescribed drugs (Polypharmacy) Patients taking three or more than three concomitant drugs are at higher risk of the occurrence of potential DDIs [27, 28]
There is an association of the occurrence of one or more potential DDIs with the number of medications prescribed per patient who took more than four medications [35]
Polypharmacy (five or more medications) is an important factor which leads to potential DDIs [5, 29,30,31, 33, 34]
Co-morbid disease Co-morbid condition independently increased the potential DDIs almost 2-folds [33]
Age Older age was found to be predisposing factors for the occurrence of DDI [5, 28, 30, 31]
Potential DDIs were occurring more frequently in the age group of 2–6 years than any other age group of the pediatric population [29]
Hospital stay The chance of taking multiple drugs increases with longer stays (greater than or equal to seven) in the hospital, which in turn increases the risk for potential DDIs [5]
International Normalized ratio (INR value) Increase in international normalized ratio value was found to be strongly associated with DDI and hence the risk of bleeding [32]
  1. Footnote: Ten studies did not report the mechanisms of drug-drug interaction