Table 6 Most common contraindication, major and moderate DDIs identified in the included studies
Drug interaction pairs | Number of interactions | Severity | Effect of interaction |
|---|---|---|---|
Clarithromycin+ simvastatin | 6 | Contraindication | Increased risk of myopathy or rhabdomyolysis |
Chlorpromazine +Thioridazine | 4 | Contraindication | Risk of an irregular heartbeat which may belief threatening |
Clarithromycin ciprofloxacin | 1 | Contraindication | Increased risk of QT interval prolongation |
Aspirin+clopidogrel | 160 | Major | Bleeding |
Aspirin+enalapril | 157 | Major | Renal dysfunction |
Spironolactone + enalapril | 101 | Major | Hyperkalemia |
Omeprazole+clopidogrel | 56 | Major | Decrease effect of clopidogrel and increased risk for thrombosis |
Spironolactone + digoxin | 47 | Major | Increased risk of digoxin toxicity |
Heparin + aspirin | 38 | Major | Increased risk of bleeding |
Aspirin+furosemide | 173 | Moderate | Fluid retention |
Haloperidol+Trihexphenidyl | 74 | Moderate | Decrease the effect of Trihexyphenidyl |
Enalapril +Furosemide | 59 | Moderate | Postural hypotension (first dose) |
Simvastatin+azithromycin | 39 | Moderate | Increased risk of rhabdomyolysis |