Skip to main content
Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway

Fig. 4

P53-dependent pathway mediated CDDP- and AKBA-induced apoptosis in GC a Western blot shows the effect of siRNA, CDDP and AKBA on protein expression in NCI - N87 cell line. P53 siRNA was successful in reducing the increase in p53 expression post treatment of CDDP and AKBA up to approximately 70%. The expression of Akt and NFkB proteins was further reduced in the combined treatment when p53 protein was down-regulated b Graphical presentation of apoptosis percentage in NCI-N87 cell line treated with different treatments showing varying degrees in apoptosis in comparison to control concentration. Apoptosis induction showed a slight trend of increase with no significant difference between treated groups with and without p53 down regulation. (*P < 0.05, **P < 0.01, ***P < 0.001). (c) Flow cytometry graphs showing the effect of different treatments on NCI-N87 cells. Each graph shows alive cells, early and late apoptotic cells, and dead cells

Back to article page