Skip to main content

Table 2 BoNT/A effects with gene list and fold changes from the DAVID Analysis

From: Dramatic neurological and biological effects by botulinum neurotoxin type A on SH-SY5Y neuroblastoma cells, beyond the blockade of neurotransmitter release

DAVID Analysis: Functional Annotation Groups Gene Title (Gene Symbol) Fold change 48 h vs. 4 h
Nervous system development cholinergic receptor, muscarinic 3 (CHRM3)
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 (SPOCK1)
neural epidermal growth factor-like EGFL like 1 (NELL1)
32.28 ↑
17.07 ↑
Proteinaceous extracellular matrix collagen, type I, alpha 2 (COL1A2) 11.99 ↓
Signaling pathways regulating pluripotency of stem cells inhibitor of DNA binding 3, dominant negative helix-loop-helix protein (ID3)
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2)
8.13 ↓
31.23 ↓
Cellular function and signal Transduction Rho GTPase activating protein 36 (ARHGAP36) 11.66↑
Apoptosis insulin like growth factor binding protein 3 (IGFBP3)
serum/glucocorticoid regulated kinase 1 (SGK1)
13.26 ↓
26.63 ↓