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Table 3 Risk factors by univariate and multivariate analysis

From: 5-Hydroxytryptamine-3 receptor antagonist and dexamethasone as prophylaxis for chemotherapy-induced nausea and vomiting during moderately emetic chemotherapy for solid tumors: a multicenter, prospective, observational study

 

Univariate analysis

multivariate analysis

 

p value

OR(95%CI)

p value

OR(95%CI)

Complete Response in the overall phase

Gender:Male vs Female

0.005

1.830[1.204–2.783]

  

Age: 65 vs < 65

0.090

1.438[0.945–2.187]

0.099

1.448[0.933–2.249]

Motion sickness: Yes vs No

0.003

0.422[0.241–0.740]

0.011

0.469[0.261–0.840]

Drinking habit: Yes vs No

0.032

1.578[1.040–2.394]

0.143

1.394[0.894–2.175]

Smoking History:Yes vs No

0.057

1.523[0.987–2.350]

  

Pregnancy associated vomiting: Yes vs Others

0.006

0.516[0.322–0.872]

0.040

0.589[0.355–0.977]

palonosetron vs 1st generation 5HT3RA

0.723

0.927[0.608–1.412]

0.070

0.560[0.300–1.048]

CBDCA-based chemotherapy vs Others

0.469

0.858[0.567–1.299]

0.027

0.494[0.264–0.922]

Total Control in overall phase

Gender:Male vs Female

0.002

1.911[1.275–2.864]

  

Age: 65 vs < 65

0.004

1.807[1.205–2.709]

0.006

1.829[1.191–2.808]

Motion sickness: Yes vs No

0.003

0.408[0.226–0.734]

0.031

0.510[0.277–0.939]

Drinking habit: Yes vs No

0.006

1.755[1.172–2.628]

0.059

1.520[0.984–2.348]

Smoking History:Yes vs No

0.194

1.313[0.871–1.979]

  

Pregnancy associated vomiting: Yes vs Others

< 0.001

0.375[0.230–0.611]

0.003

0.460[0.275–0.770]

palonosetron vs 1st generation 5HT3RA

0.445

1.172[0.780–1.759]

  

CBDCA-based chemotherapy vs Others

0.364

0.831[0.557–1.239]

0.063

0.666[0.434–1.023]

  1. Backward selection method with an entry and exit criteria of 0.2
  2. OR Odds ratio, CI Confidence interval, 5HT3RA 5-hydroxytryptamine-3 receptor antagonist, CBDCA Carboplatin