Table 7 Mixed effects model results for selected congenital anomalies
Parameter | Estimate (95%C.I.) | P-Value |
|---|---|---|
Cardiovascular | ||
 Atrial_Septal_Defect | ||
  Cannabis | 0.053 (0.011, 0.096) | 0.0280 |
 PDA | ||
  Cannabis | 0.039 (− 0.004, 0.082) | 0.0974 |
 Tetralogy_Fallot | ||
  Cannabis | 0.079 (0.024, 0.133) | 0.0135 |
 GIT | ||
  Cigarettes: Alcohol: Cannabis | 0.022 (0.004, 0.041) | 0.0362 |
  Cigarettes | 0.759 (0.064, 1.455) | 0.0581 |
  Cigarettes: Alcohol | −0.219 (−0.424, − 0.013) | 0.0637 |
  Cigarettes: Cannabis | −0.082 (− 0.145, − 0.019) | 0.0285 |
 Small_Intestinal_Stenosis_Atresia | ||
  Alcohol: Cannabis | 0.02 (0.008, 0.032) | 0.0059 |
 GUT_Defects | ||
  Cigarettes | 0.278 (0.043, 0.513) | 0.0405 |
  Cigarettes: Alcohol | −0.085 (−0.156, − 0.015) | 0.0370 |
  Cigarettes: Alcohol: Cannabis | 0.008 (0.002, 0.014) | 0.0295 |
  Cigarettes: Cannabis | −0.027 (− 0.048, − 0.006) | 0.0289 |
Chromosomal | ||
 Chromosomal | ||
  Cannabis | 0.084 (0.019, 0.149) | 0.0253 |
  Cigarettes: Alcohol: Cannabis | −0.001 (− 0.002, 0) | 0.0701 |
 Downs_Syndrome | ||
  Cigarettes | 0.208 (0.024, 0.392) | 0.0464 |
  Cigarettes: Alcohol: Cannabis | 0.001 (0, 0.001) | 0.0636 |
  Cigarettes: Alcohol | −0.071 (− 0.124, − 0.018) | 0.0231 |
Body Wall | ||
 Musculoskeletal | ||
  Cannabis | 2.686 (0.671, 4.701) | 0.0241 |
  Cigarettes: Alcohol: Cannabis | 0.038 (0.01, 0.067) | 0.0236 |
  Alcohol: Cannabis | −0.79 (−1.385, − 0.195) | 0.0246 |
  Cigarettes: Cannabis | −0.131 (− 0.228, − 0.034) | 0.0228 |
 Gastroschisis | ||
  Cannabis | 0.065 (0.016, 0.115) | 0.0207 |
 Exomphalos | ||
  Alcohol: Cannabis | 0.042 (0.002, 0.082) | 0.0596 |
  Cigarettes: Cannabis | −0.006 (−0.011, 0) | 0.0874 |