Bioprospecting the antimicrobial, antibiofilm and antiproliferative activity of Symplocos racemosa Roxb. Bark phytoconstituents along with their biosafety evaluation and detection of antimicrobial components by GC-MS

Table 6 Effect of Symplocos racemosa flavonoids on biochemical parameters in acute oral toxicity study

Parameters	Male			Female
Parameters	Control^a	Treated^a	p-value	Control^a	Treated^a	p-value
Urea (Mmol/L)	42.633 ± 0.839	42.460 ± 0.553	0.867	40.13 ± 0.991	40.183 ± 0.539	0.963
Creatinine (μmol/L)	0.774 ± 0.026	0.765 ± 0.019	0.799	0.618 ± 0.024	0.601 ± 0.012	0.535
Total bilirubin (μmol/L)	2.376 ± 0.093	2.371 ± 0.063	0.882	1.76 ± 0.025	1.772 ± 0.014	0.677
Aspartate aminotransferase (AST)(U/L)	208.96 ± 4.192	209.11 ± 2.312	0.976	160.66 ± 2.708	159.76 ± 1.574	0.780
Alanine aminotransferase (ALT) (U/L)	79.95 ± 2.095	81.698 ± 0.591	0.441	61.33 ± 2.677	61.501 ± 1.338	0.955
Alkaline phosphatase (ALP) (U/L)	258.3 ± 2.510	256.89 ± 1.344	0.633	183.33 ± 1.612	181.733 ± 0.794	0.403

^aValues are expressed as mean ± SEM (n = 6 for each group). There was no significant difference (p > 0.05) between the test and control groups as indicated by one way ANOVA followed by Post hoc Tukey’s t-test

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