Fig. 5

Effects of carnosine on the expression of p38 MAPK signaling pathway. The levels of sek-1 (a) and pmk-1 (b) mRNA in C. elegans were detected by PCR. c The survival rate of worms were not altered by LPS treatment in pmk-1(km25), sek-1(km4) mutants. Western blot analysis of SEK1 (d) and p-p38 (e) protein levels in C. elegans after LPS exposure. Date are presented as means±SEM. ###P < 0.001, ##P < 0.01, #P < 0.05, vs.the vehicle group; ***P < 0.001, **P < 0.01, *P < 0.05, vs. the LPS + vehicle group