TY - JOUR AU - Afsharirad, Tayebeh AU - Tahmasvand, Raheleh AU - Amini, Mohsen AU - Daraei, Bahram AU - Salimi, Mona PY - 2020 DA - 2020/11/19 TI - Two novel anticancer compounds with minimum cardiotoxic property JO - BMC Pharmacology and Toxicology SP - 79 VL - 21 IS - 1 AB - Although two novel synthesized compounds with tri-aryl structures; 3-(4-chlorophenyl)-5-(4-fluorophenyl)-4-phenyl-4,5-dihydro-1,2,4-oxadiazole (A) and 3,5-bis-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1,2,4-oxadiazole (B) have been previously demonstrated to possess remarkable anti-breast cancer activity, their cardiotoxicity remains a major concern due to their mechanism of action. To address this concern, we assessed the ability of these compounds to cause toxicity towards H9c2 cardiomyocytes as an in vitro model of cardiotoxicity. SN - 2050-6511 UR - https://doi.org/10.1186/s40360-020-00457-8 DO - 10.1186/s40360-020-00457-8 ID - Afsharirad2020 ER -