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Fig. 4 | BMC Pharmacology and Toxicology

Fig. 4

From: Attenuation of LPS-induced acute lung injury by continentalic acid in rodents through inhibition of inflammatory mediators correlates with increased Nrf2 protein expression

Fig. 4

Effects of continentalic acid (10, 50 and 100 mg/kg) treatment on LPS-induced pro-inflammatory cytokines such as (a) IL-1β, (b) IL-6 and (c) TNF-α in lung tissue. The ELISA assay was performed to assess the cytokines production in all the treated groups following LPS-induced ALI. The LPS administration markedly increase the production of inflammatory cytokines in the negative control group, however, the continentalic acid treatment showed marked reduction in the inflammatory cytokines. The results of the assay were shown in the percentage. All data were expressed as mean (n = 8) ± SD. ###p < 0.001 compared to control group; *p < 0.05, **p < 0.01 and ***p < 0.001 compared to LPS-treated group

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