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Fig. 5 | BMC Pharmacology and Toxicology

Fig. 5

From: Attenuation of LPS-induced acute lung injury by continentalic acid in rodents through inhibition of inflammatory mediators correlates with increased Nrf2 protein expression

Fig. 5

The effect of the continentalic acid (10 mg/kg, 50 mg/kg and 100 mg/kg) on the histopathological changes following LPS-induced lung injury using H and E staining in all the treated groups such as vehicle control (a and f), LPS 5 mg/kg (b and g), LPS (5 mg/kg) + Vehicle (c and h), dexamethasone (d and i) and CNT (e and j). The histological parameters that were assessed following LPS-induced lung injury includes (a-e) the neutrophilic infiltration, edema and fibrosis. Similarly, the panels (f-j) includes the changes in the bronchial architecture following LPS-induced ALI. The H and E staining showed significant improvement in the histopathological parameters in the treatment control compared to the negative control. Similarly, the histological changes (k) were quantified using score of 0–4 and the continentalic acid improved the histological features. The MPO assay (l) performed to assess the level of the neutrophilic indicator in the lung tissue following establishing ALI. The continentalic acid showed marked reduction in the MPO level compared to the negative control. All data were expressed as mean (n = 8) ± SD. ###p < 0.001 compared to control group; *p < 0.05, **p < 0.01 and ***p < 0.001 compared to LPS-treated group

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