Indexs | Control | H-BH4 | L-BH4 | H-N | L-N | L-N&L-BH4 | L-N&H-BH4 | H-N&L-BH4 | H-N&H-BH4 |
---|---|---|---|---|---|---|---|---|---|
(n = 6) | (n = 6) | (n = 6) | (n = 6) | (n = 6) | (n = 6) | (n = 6) | (n = 6) | (n = 6) | |
Body weight g | 249.8± 5.0 | 251.2± 5.5 | 248.6± 5.2 | 251.1± 3.5 | 248.6± 5.7 | 257.1±5.9 | 253.2±11.9 | 253.3±3.8 | 247.3± 2.8 |
Systolic BP,mm Hg | 210.0±10.1 | 193.4±19.4 | 196.5±9.4 | 185.2±9.7** | 190.1±23.8 | 185.5±16.6* | 188.4±20.8* | 186.±16.0* | 185.1±11.5* |
Heart rate, bpm | 447±37 | 448±12## | 436±34 | 347±11* | 366±7 | 361±5 | 343±57 | 332±10*# | 331±6*## |
Diastolic measures | |||||||||
E` | 29.83±1.16 | 34.66±1.03**## | 33.00±1.09**## | 48.00±0.89**## | 31.16±1.17*## | 37.83±1.16**## | 28.00±0.89*## | 33.00±1.09**## | 29.50±1.04## |
E/E′ | 23.49±0.95 | 15.25±0.36** | 19.65±0.63**## | 18.63±0.45**## | 20.45±1.40*## | 15.43±0.75** | 19.65±0.10**## | 17.38±0.77*## | 13.72±0.46## |
E′/A′ | 0.77±0.03 | 1.19±0.03** | 0.99±0.12**# | 1.21±0.06** | 1.07±0.05** | 1.21±0.09** | 1.03±0.07** | 1.10±0.03**## | 1.32±0.05## |
Invasive measure | |||||||||
Heart rate | 399.1±34.2 | 371.3±50.2 | 398.4±38.6 | 354.0±24.1* | 368.5±19.4 | 364.8±41.3 | 385.5±15.1 | 349.1±39.8** | 353.9±33.2* |
Systolic function | |||||||||
Max LVSP | 168.06±3.94 | 144.8±7.67** | 131.81±6.09** | 124.81±8.2** | 139.35±4.3** | 162.37±9.06 | 136.3±4.33** | 153.59±9.1* | 146.17±0.64* |
+dP/dtmax, mm Hg/s | 8338.20±366.75 | 8268.8±277.50 | 7257.63±73.54## | 7724.35±107.6## | 8279.39±246.2 | 8228.84±76.82 | 6732.±96*## | 5212±326**## | 4642±240**## |
Diastolic function | |||||||||
LVEDP | 24.56±4.18 | 14.55±1.82** | 16.2±1.21** | 15.95±1.50**# | 17.99±2.04** | 14.56±1.40** | 16.86±2.83** | 14.89±0.52** | 12.43±3.04## |
-dP/dtmin,mmHg/s | -6992±123 | -6780±284## | -6568±149## | -6599±287## | -6610±195## | -7753±223* | -6598±134## | -6854±224*## | -7787±489*## |
-dP/dtmin/lvsp | -41.65±1.4 | -46.98±4.32* | -49.91±2.72** | -53.02±4.0** | -47.4±0.83* | -47.9±3.98* | -48.4±2.48** | -40.28±3.44 | -55.62±1.60 |
tau | 38.28±2.48 | 25.58±0.63** | 23.67±0.63** | 27.84±2.05** | 29.38±2.98**## | 25.42±1.38** | 22.53±2.65**## | 25.60±0.48** | 20.55±4.12*## |