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Table 3 Comparison of indicators among control and experimental groups

From: Nebivolol combined with tetrahydrobiopterin affects diastolic function in spontaneously hypertensive rats via the nitric oxide/cyclic guanosine monophosphate signalling pathway

Indexs

Control

H-BH4

L-BH4

H-N

L-N

L-N&L-BH4

L-N&H-BH4

H-N&L-BH4

H-N&H-BH4

(n = 6)

(n = 6)

(n = 6)

(n = 6)

(n = 6)

(n = 6)

(n = 6)

(n = 6)

(n = 6)

Body weight g

249.8± 5.0

251.2± 5.5

248.6± 5.2

251.1± 3.5

248.6± 5.7

257.1±5.9

253.2±11.9

253.3±3.8

247.3± 2.8

Systolic BP,mm Hg

210.0±10.1

193.4±19.4

196.5±9.4

185.2±9.7**

190.1±23.8

185.5±16.6*

188.4±20.8*

186.±16.0*

185.1±11.5*

Heart rate, bpm

447±37

448±12##

436±34

347±11*

366±7

361±5

343±57

332±10*#

331±6*##

Diastolic measures

 E`

29.83±1.16

34.66±1.03**##

33.00±1.09**##

48.00±0.89**##

31.16±1.17*##

37.83±1.16**##

28.00±0.89*##

33.00±1.09**##

29.50±1.04##

 E/E′

23.49±0.95

15.25±0.36**

19.65±0.63**##

18.63±0.45**##

20.45±1.40*##

15.43±0.75**

19.65±0.10**##

17.38±0.77*##

13.72±0.46##

 E′/A′

0.77±0.03

1.19±0.03**

0.99±0.12**#

1.21±0.06**

1.07±0.05**

1.21±0.09**

1.03±0.07**

1.10±0.03**##

1.32±0.05##

Invasive measure

 Heart rate

399.1±34.2

371.3±50.2

398.4±38.6

354.0±24.1*

368.5±19.4

364.8±41.3

385.5±15.1

349.1±39.8**

353.9±33.2*

Systolic function

 Max LVSP

168.06±3.94

144.8±7.67**

131.81±6.09**

124.81±8.2**

139.35±4.3**

162.37±9.06

136.3±4.33**

153.59±9.1*

146.17±0.64*

 +dP/dtmax, mm Hg/s

8338.20±366.75

8268.8±277.50

7257.63±73.54##

7724.35±107.6##

8279.39±246.2

8228.84±76.82

6732.±96*##

5212±326**##

4642±240**##

Diastolic function

 LVEDP

24.56±4.18

14.55±1.82**

16.2±1.21**

15.95±1.50**#

17.99±2.04**

14.56±1.40**

16.86±2.83**

14.89±0.52**

12.43±3.04##

 -dP/dtmin,mmHg/s

-6992±123

-6780±284##

-6568±149##

-6599±287##

-6610±195##

-7753±223*

-6598±134##

-6854±224*##

-7787±489*##

 -dP/dtmin/lvsp

-41.65±1.4

-46.98±4.32*

-49.91±2.72**

-53.02±4.0**

-47.4±0.83*

-47.9±3.98*

-48.4±2.48**

-40.28±3.44

-55.62±1.60

 tau

38.28±2.48

25.58±0.63**

23.67±0.63**

27.84±2.05**

29.38±2.98**##

25.42±1.38**

22.53±2.65**##

25.60±0.48**

20.55±4.12*##

  1. Notes: Values are means ± SD. WKY, Wistar-Kyoto rats; SHR, spontaneously hypertensive rat; BP, blood pressure; E = peak early diastolic LV filling velocity; A = peak late diastolic LV filling velocity; E/A = peak E and A velocity ratio; E’and A’, maximal velocity of mitral annulus during early and late diastole; LVEDd, LV end-diastolic dimension; LVSP, LV systolic pressure; tau, time constant of isovolumic LV relaxation.*represents compared with control, P < 0.05,**represents P < 0.01; # represents compared with group L-N&L-BH4, P < 0.05, ## represents P < 0.01