Skip to main content

Table 3 Time courses of heart rate, systolic and diastolic blood pressure during and after infusion of landiolol for 60 min on top of continuous dobutamine infusion in healthy volunteers of European ancestry (n = 16)

From: Pharmacodynamic and pharmacokinetic behavior of landiolol during dobutamine challenge in healthy adults

Time (min) HR [IQR] (bpm) SBP [IQR] (mmHg) DBP [IQR] (mmHg)
baseline 65.5 [59.3, 72.5] 107.0 [100.0, 112.3] 72.0 [68.0, 75.5]
-10 101.0 [91.8, 113.0] 137.5 [125.8, 152.8] 76.0 [71.8, 80.5]
-5 107.5 [100.8, 117.1] 133.0 [126.3, 150.1] 77.0 [72.8, 83.0]
0 112.0 [100.5, 120.8] 134.0 [123.0, 145.5] 75.0 [69.8, 85.0]
2 112.5 [102.4, 117.5]
4 103.5 [97.8, 109.8] 139.5 [124.8, 151.3] 77.0 [68.8, 85.0]
6 92.5 [88.0, 99.5]
8 85.5 [79.1, 91.0] 126.0 [121.5, 137.3] 77.0 [72.0, 82.5]
12 83 [79.4, 87.3]
16 79.8 [72.0, 84.3] 122.5 [114.5, 135.0] 74.5 [70.0, 79.8]
20 79.3 [76.5, 82.0]
28 77.5 [72.3, 78.3] 121.5 [111.0, 129.8] 74.0 [65.5, 79.3]
36 75.5 [71.5, 82.3]
44 73.0 [70.0, 78.3] 119.0 [110.8, 124.3] 71.0 [65.5, 75.3]
60 71.0 [69.0, 74.3] 121.5 [112.0, 124.3] 73.5 [66.0, 79.8]
62 75.0 [70.9, 81.8]
64 75.5 [68.8, 79.3] 118.0 [114.8, 124.3] 74.0 [62.8, 79.5]
66 75.8 [69.8, 87.5]
68 78.5 [70.0, 86.9] 122.5 [114.5, 134.5] 68.5 [63.8, 76.0]
72 85.0 [77.5, 90.0]
76 91.0 [76.8, 98.5] 128.3 [121.3, 135.5] 70.3 [64.5, 79.3]
80 89.5 [82.8, 104.6]
88 105.0 [94.8, 111.6] 122.8 [117.3, 143.0] 72.0 [69.6, 79.8]
96 86.5 [75.5, 99.5]
104 78.0 [71.0, 84.0] 109.5 [101.8, 116.5] 73.0 [63.5, 77.3]
120 80.8 [70.0, 82.0] 106.5 [99.8, 114.3] 69.5 [62.8, 74.3]
135 74.5 [65.0, 81.8] 104.5 [96.3, 109.3] 66.5 [61.5, 74.0]
150 71.5 [65.5, 81.0] 106.0 [95.0, 112.0] 67.0 [62.5, 75.0]
165 75.0 [66.3, 82.9] 105.0 [97.5, 109.3] 66.5 [62.8, 74.3]
180 72.5 [65.5, 82.8] 102.0 [98.0, 112.3] 67.5 [62.5, 73.0]
  1. IQR Interquartile range