Table 2 Pooled results of TC, non-HDL-C, ApoB and hsCRP reductions by bempedoic acid
Subgroups | Number of studies | Sample size | ES (95% CI) | I2(%) | |
|---|---|---|---|---|---|
Experimental | Control | Â | Â | ||
TC | |||||
 BA+Stain VS Stain | 4 | 2050 | 1045 | −11.40 (−12.15, −10.64) | 2.4 |
 BA+EZE VS EZE | 1 | 86 | 86 | −10.40 (−16.15, −4.65) | – |
 BA+EZE VS PBO | 1 | 86 | 41 | −27.10(−35.10, −19.10) | – |
Non-HDL-C | |||||
 BA+Stain VS Stain | 4 | 2050 | 1045 | −13.57(−14.52, −12.62) | 0 |
 BA+EZE VS EZE | 1 | 86 | 86 | −12.10(−19.15, −5.05) | – |
 BA+EZE VS PBO | 1 | 86 | 41 | −17.80(−25.10, −10.50) | – |
 BA VS PBO | 1 | 224 | 107 | −17.10(−20.50, −13.70) | – |
ApoB | |||||
 BA+Stain VS Stain | 4 | 1998 | 1042 | −12.73(−14.71, −10.75) | 45.8 |
 BA+EZE VS EZE | 1 | 82 | 84 | −9.30(−16.50.-2.10) | – |
 BA+EZE VS PBO | 1 | 82 | 38 | −12.80(−20.30, −5.30) | – |
 BA VS PBO | 1 | 224 | 107 | −15.50(−18.80, −12.20) | – |
hsCRP | |||||
 BA+Stain VS Stain | 4 | 2185 | 1109 | −20.72(−29.21, −12.23) | 77.8 |
 BA+EZE VS EZE | 1 | 80 | 79 | −25.60(−44.50, −6.70) | – |
 BA+EZE VS PBO | 1 | 80 | 39 | −46.10(−77.60, −14.60) | – |