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Table 2 Comparison of comorbidities in patients with adverse drug reactions between younger patients and older adults

From: Common causes and characteristics of adverse drug reactions in older adults: a retrospective study

 

Total

N = 14,864 (%)

< 65 years

N = 11,427 (%)

≥ 65 years

N = 3437 (%)

P value

Comorbid conditions

 Injury, poisoning, and other consequences of external causes

3771 (20.0)

3246 (28.4)

525 (15.3)

< 0.001

 Diseases of the digestive system

3496 (18.6)

2676 (23.4)

820 (23.9)

0.594

 Neoplasms

3375 (17.9)

2462 (21.5)

913 (26.6)

< 0.001

 Diseases of the respiratory system

2744 (14.6)

2207 (19.3)

537 (15.6)

< 0.001

 Diseases of the skin and subcutaneous tissue

2112 (11.2)

1807 (15.8)

305 (8.9)

< 0.001

 Diseases of the circulatory system

2057 (10.9)

1222 (10.7)

835 (24.3)

< 0.001

 Diseases of the musculoskeletal system and connective tissue

1821 (9.7)

1313 (11.5)

508 (14.8)

< 0.001

 Diseases of the genitourinary system

1666 (8.8)

1244 (10.9)

422 (12.3)

0.028

 Certain infectious and parasite disease

1644 (8.7)

1304 (11.4)

340 (9.9)

0.010

 Endocrine, nutritional, and metabolic diseases

1558 (8.3)

1087 (9.5)

471 (13.7)

< 0.001

 Diseases of the nervous system

1228 (6.5)

959 (8.4)

269 (7.8)

0.283

  1. Values represent numbers of patients with percentages in parentheses. Plus-minus values are means ± standard deviations. P values were obtained from the chi-square test with Yates’ correction