Table 3 Ratios of serious ADRs to total ADRs for the 20 most common culprit drugs classified by active ingredient

Analgesics

41/2401 (1.7)

16/929 (1.7)

1.01 (0.56–1.81)

0.977

 Tramadol

24/1606 (1.5)

10/727 (1.4)

0.92 (0.44–1.93)

0.824

 Fentanyl

3/209 (1.4)

3/84 (3.6)

2.54 (0.50–12.86)

0.243

 Nefopam

0/308 (0)

0/70 (0)

N/A

N/A

 Acetaminophen

14/278 (5.0)

3/48 (6.3)

1.26 (0.35–4.55)

0.727

Contrast media

59/2744 (2.2)

34/775 (4.4)

2.09 (1.36–3.21)

0.001

 Iohexol

4/848 (0.5)

9/247 (3.6)

7.98 (2.44–26.14)

< 0.001

 Iopamidol

24/982 (2.4)

7/244 (2.9)

1.18 (0.50–2.77)

0.705

 Iomeprol

7/420 (1.7)

6/93 (6.5)

4.07 (1.34–12.40)

0.008

 Iopromide

16/220 (7.3)

4/83 (4.8)

0.65 (0.21–1.99)

0.443

 Iodixanol

2/103 (1.9)

5/60 (8.3)

4.59 (0.86–24.45)

0.052

 Ioversol

6/171 (3.5)

3/48 (6.3)

1.83 (0.44–7.62)

0.398

Anti-bacterial drugs

60/864 (6.9)

37/424 (8.7)

1.28 (0.84–1.96)

0.255

 Ceftriaxone

16/324 (4.9)

13/104 (12.5)

2.75 (1.28–5.93)

0.008

 Ciprofloxacin

8/174 (4.6)

5/84 (6.0)

1.31 (0.42–4.14)

0.641

 Cefpiramide

1/152 (0.7)

1/72 (1.4)

2.13 (0.13–34.49)

0.587

 Piperacillin

3/52 (5.8)

7/58 (12.1)

2.24 (0.55–9.17)

0.251

 Vancomycin

10/131 (7.6)

7/56 (12.5)

1.73 (0.62–4.08)

0.289

 Cefaclor

22/31 (71.0)

4/50 (8.0)

0.04 (0.01–0.13)

< 0.001

Anti-inflammatory and anti-rheumatic drugs

172/2009 (8.6)

39/232 (16.8)

2.16 (1.48–3.15)

< 0.001

 Acetic acid

40/507 (7.9)

10/83 (12.0)

1.60 (0.77–3.34)

0.207

 Acetylsalicylic acid

90/749 (12.0)

19/82 (23.2)

2.21 (1.26–3.86)

0.005

 Propionic acid

42/753 (5.6)

10/67 (14.9)

2.97 (1.42–6.23)

0.003

 Ranitidine

15/251 (6.0)

5/88 (5.7)

0.95 (0.33–2.69)

0.920