Table 4 Clinical manifestations of ADRs according to causative drugs categorized by ATC code
From: Common causes and characteristics of adverse drug reactions in older adults: a retrospective study
WHO-ART SOC | Analgesic drugs | Contrast media | Antibiotics | ||||||
|---|---|---|---|---|---|---|---|---|---|
< 65 n = 4083 (%) | ≥ 65 n = 1161 (%) | P value | < 65 n = 2737 (%) | ≥ 65 n = 757 (%) | P value | < 65 n = 2521 (%) | ≥ 65 n = 710 (%) | P value | |
Skin | 2200 (53.9) | 301 (25.9) | < 0.001 | 2337 (85.4) | 628 (83.0) | 0.174 | 1653 (65.6) | 427 (60.1) | 0.878 |
Gastrointestinal | 1947 (47.7) | 793 (68.3) | < 0.001 | 341 (12.5) | 98 (12.9) | 0.843 | 982 (39.0) | 252 (35.5) | 1.000 |
Nervous system | 781 (19.1) | 228 (19.6) | 0.067 | 231 (8.4) | 53 (7.0) | 0.207 | 286 (11.3) | 75 (10.6) | 0.907 |
General | 534 (13.1) | 110 (9.5) | 0.035 | 319 (11.7) | 86 (11.4) | 0.807 | 404 (16.0) | 94 (13.2) | 0.409 |
Respiratory | 648 (15.9) | 112 (9.6) | < 0.001 | 291 (10.6) | 67 (8.9) | 0.156 | 339 (13.4) | 60 (8.5) | 0.007 |
Heart-related | 198 (4.8) | 68 (5.9) | 0.039 | 70 (2.6) | 46 (6.1) | < 0.001 | 131 (5.2) | 27 (3.8) | 0.344 |
Anaphylaxis | 240 (5.9) | 52 (4.5) | 0.302 | 44 (1.6) | 23 (3.0) | 0.019 | 234 (9.3) | 41 (5.8) | 0.025 |
SCARs | 5 (0.1) | 4 (0.3) | 0.090 | 4 (0.1) | 1 (0.1) | 1.000 | 14 (0.6) | 7 (1.0) | 0.170 |