Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product

Table 1 Description of the test articles and dosing for the 2 stages of this pharmacokinetic study

S-adenosylmethionine Test Article Name	Dosage Form/ Route of Administration	Stage 1 dosing	Stage 2 dosing
MSI-195^a	Tablet/ Oral	• 400 mg (1 x 400 mg)	• 800 mg (2 x 400 mg)
		• 800 mg (2 x 400 mg)
		• 1600 mg (4 x 400 mg)
SAM-e Complete^TMb	Tablet/Oral	n/a	• 1600 mg (4 x 400 mg)

^aMSI-195 is Methylation Sciences’ proprietary oral enteric coated tablet formulation of S-adenosylmethionine
^bSAM-e Complete™ is a commercial dietary supplement oral enteric coated tablet formulation manufactured by Pharmavite in the United States under the NatureMade™ brand

ISSN: 2050-6511