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Table 7 Gender Effect Evaluation of S-Adenosylmethionine, Stage 2

From: Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product

PARAMETER

MSI-195

SAM-e Complete™

800 mg

1600 mg

Fasting

Fed

Fasting

Male, (n = 7)

Female, (n = 17)

Male, (n = 7)

Female, (n = 17)

Male, (n = 7)

Female, (n = 17)

Cmax (ng/mL)

3832.0

3053.9

1144.4

1591.3

1205.8

2304.9

Tmax (hours) *

3.50

4.50

12.00

14.00

5.00

6.00

AUCt (ng·h/mL)

8693.5

8743.1

4599.2

5482.3

5098.7

7182.7