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Table 8 Dose corrected comparison of SAMe PK data across studies

From: Pharmacokinetic study of a novel oral formulation of S-adenosylmethionine (MSI-195) in healthy subjects: dose escalation, food effect and comparison to a commercial nutritional supplement product

 

Reference

Route

Dose

Parameters

Parameters Corrected for Dose

    

Cmax

AUCa

T1/2

Cmax

AUCT

    

ng/ml

ng/ml*h

h

(ng/ml)/mg

(ng/ml*h)/mg

MSI Study

Stage 1:

       

MSI-195

Oral

400

1045.4

4643.9

16.0

2.6

11.6

MSI-195

Oral

800

3255.5

9360.6

8.9

4.1

11.7

MSI-195

Oral

1600

4808.8

16,511.0

7.8

3.0

10.3

Stage 2:

       

MSI-195 Fast

Oral

800

3280.8

9434.4

11.5

4.1

11.8

MSI-195 Fed

Oral

800

1461.0

5224.7

33

1.8

6.5

SAMe (NM)

Oral

1600

1984.3

6643.8

9.3

1.2

4.2

Literature Studies

Loehrer et al. [17]

Oral

400

144

489

1.7

0.4

1.2

Yang et al. [12]

Oral

1000

974

4748

6.2

1.0

4.7

Yang et al. [12]

IV

1000

67,600

162,000

4.1

67.6

162.0

Guilidori et al. [16]

IV

100

8320

7833

1.35

83.2

78.3

Guilidori et al. [16]

IV

500

31,300

42,500

1.68

62.6

85.0

Stramentinoli et al. [18]

IM

35

-

4300

1.35

-

122.9

Stramentinoli et al. [18]

IV

35

-

4000

1.35

-

114.3