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Table 1 Baseline characteristics of the study population (N = 461,034)

From: Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale

Characteristics Total
(N = 461,034)
Case
(N = 21,954)
Control
(N = 439,080)
P value
N (%) N (%) N (%)
Age, mean [SD] 76.1 [7.1] 76.2 [7.1] 76.1 [7.1] 0.8844
 65–74 204,246 (44.3) 9726 (44.3) 194,520 (44.3) 0.9743
 75–84 194,220 (42.1) 9238 (42.1) 184,982 (42.1) 0.9743
  ≥ 85 62,568 (13.6) 2990 (13.6) 59,578 (13.6) 0.9743
Gender, male 180,351 (39.1) 8627 (39.3) 171,724 (39.1) 0.5819
CCI score, mean [SD] 2.11 [1.93] 2.25 [2.16] 2.10 [1.92] <.0001
 0 97,658 (21.2) 4658 (21.2) 93,000 (21.2) 0.9917
 1–2 198,912 (43.1) 9468 (43.1) 189,444 (43.2) 0.9917
  ≥ 3 164,464 (35.7) 7828 (35.7) 156,636 (35.7) 0.9917
Health insurance type
 Health insurance 403,869 (87.6) 19,228 (87.6) 384,641 (87.6) 0.9355
 Medical aid 57,165 (12.4) 2726 (12.4) 54,439 (12.4) 0.9355
Co-morbid condition
 Diabetes Mellitus 136,783 (29.7) 6702 (30.5) 130,081 (29.6) 0.0043
 COPD 73,613 (16.0) 4126 (18.8) 69,487 (15.8) <.0001
 Cerebrovascular disease 64,855 (14.1) 3732 (17.0) 61,123 (13.9) <.0001
 Coronary artery disease 59,108 (12.8) 3319 (15.1) 55,789 (12.7) <.0001
 Liver failure 37,934 (8.2) 2215 (10.1) 35,719 (8.1) <.0001
 Congestive heart failure 30,984 (6.7) 1813 (8.3) 29,171 (6.6) <.0001
 Cancer 28,152 (6.1) 1640 (7.5) 26,512 (6.0) <.0001
 Renal failure 10,927 (2.4) 778 (3.5) 10,149 (2.3) <.0001
 Parkinson's disease 10,347 (2.2) 749 (3.4) 9598 (2.2) <.0001
Medication Use
No. of concomitant drugs, mean [SD] 4.4 [3.9] 5.2 [4.4] 4.4 [3.9] <.0001
  < 5 258,095 (56.0) 10,829 (49.3) 247,266 (56.3) <.0001
 Polypharmacy (5–9) 153,316 (33.3) 7580 (34.5) 145,736 (33.2) <.0001
 Excessive polypharmacy (≥ 10) 49,623 (10.8) 3545 (16.2) 46,078 (10.5) <.0001
Use of sedative drugs 225,843 (49.0) 13,797 (62.9) 212,046 (48.3) <.0001
Use of digoxin 6610 (1.4) 406 (1.9) 6204 (1.4) <.0001
Use of insulin 6077 (1.3) 517 (2.4) 5560 (1.3) <.0001
Use of warfarin 4278 (0.9) 300 (1.4) 3978 (0.9) <.0001
  1. SD standard deviation, CCI Charlson Comorbidity Index, COPD Chronic obstructive pulmonary disease