BMC Pharmacology and Toxicology

Table 4 The top 20 drugs contributing to anticholinergic burden measured by each scale

From: Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale

KABS			ARS			ACB			ADS
Score	Drug	%	Score	Drug	%	Score	Drug	%	Score	Drug	%
1	ranitidine^a	11.4	1	ranitidine^a	29.8	1	hydrochlorothiazide	15.7	2	ranitidine^a	24.3
3	dimenhydrinate	8.0	3	chlorpheniramine^a	18.8	1	ranitidine^a	10.3	3	dimenhydrinate	8.6
3	chlorpheniramine^a	7.2	2	cimetidine^a	12.8	3	dimenhydrinate	7.2	3	chlorpheniramine^a	7.7
2	tramadol	6.7	3	amitriptyline^a	4.7	3	chlorpheniramine^a	6.5	2	cimetidine^a	5.2
3	solifenacin	6.4	2	cetirizine	4.5	3	solifenacin	5.7	1	furosemide	5.0
2	cimetidine^a	4.9	1	levodopa	4.3	1	furosemide	4.2	1	isosorbide	4.3
1	furosemide	4.7	2	tolterodine^a	3.9	1	isosorbide	3.6	1	tramadol	3.6
3	propiverine	3.5	3	hydroxyzine^a	2.6	3	propiverine	3.1	1	nifedipine	3.3
1	escitalopram	3.2	2	amantadine^a	1.7	1	escitalopram	2.8	1	alprazolam	3.2
1	alprazolam	3.0	1	paroxetine^a	1.6	1	nifedipine	2.8	3	tolterodine^a	2.4
3	octylonium^b	2.6	3	butylscopolamine^a	1.4	1	alprazolam	2.7	1	diltiazem	2.3
1	levocetirizine	2.5	2	loratadine	1.2	1	atenolol	2.4	1	famotidine	2.0
1	trimebutine^b	2.3	2	nortriptyline^a	1.2	1	levocetirizine	2.3	1	nizatidine	1.9
3	tolterodine^a	2.3	1	mirtazapine	1.2	1	cimetidine^a	2.2	3	amitriptyline^a	1.9
3	fesoterodine	2.0	3	imipramine^a	1.2	3	tolterodine^a	2.0	1	prednisolone	1.9
3	amitriptyline^a	1.8	1	quetiapine^a	1.1	1	doxazosin	1.8	1	methylprednisolone	1.8
1	prednisolone	1.8	2	baclofen	0.9	3	fesoterodine	1.8	1	diazepam	1.8
1	diazepam	1.6	2	loperamide^a	0.9	3	paroxetine^a	1.7	1	digoxin	1.6
1	digoxin	1.5	1	trazodone	0.9	3	amitriptyline^a	1.6	1	dexamethasone	1.3
2	paroxetine^a	1.2	2	olanzapine^a	0.8	1	prednisolone	1.6	1	lorazepam	1.3

KABS Korean Anticholinergic Burden Scale, ARS Anticholinergic Risk Scale, ACB Anticholinergic Cognitive Burden, ADS Anticholinergic Drug Scale
^aDrugs common to all four anticholinergic drug scales
^bDrugs included only in the KABS list

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ISSN: 2050-6511

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