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Table 2 Downregulated genes in Cy-exposed mice

From: Extended adverse effects of cyclophosphamide on mouse ovarian function

Fold Change p-value Gene Symbol Description
4.92 0.0009 Ighv10–1 Immunoglobulin heavy variable 10–1
4.71 0.0402 Igk-V1 Immunoglobulin kappa chain variable 1
4.49 0.0204 Igkv6–14 Immunoglobulin kappa variable 6–14
4.05 0.0095 Ighv1–62-2 Immunoglobulin heavy variable 1–62-2
4.05 0.0095 Ighv1–71 Immunoglobulin heavy variable 1–71
3.71 0.0235 Igh-VJ558 Immunoglobulin heavy chain (J558 family)
3.25 0.0402 Ighv5–16 Immunoglobulin heavy variable 5–16
3.19 0.0184 Igkv5–45 Immunoglobulin heavy chain variable 5–45
2.93 0.0003 Nlrp14 NLR family, pyrin domain containing 14
2.79 0.0003 Oas1d 2–5 oligoadenylate synthetase 1D
2.70 0.0009 Slc38a3 solute carrier family 38, member 3
2.65 0.0203 Mug-ps1 Murinoglobulin, pseudogene 1
2.63 0.0049 Igkv8–28 Immunoglobulin kappa variable 8–28
2.59 3.59E-05 Zp2 zona pellucida glycoprotein 2
2.56 0.0001 Nlrp5 NLR family, pyrin domain containing 5
2.54 0.0002 Khdc1b KH domain containing 1B
2.45 0.0009 Khdc1a KH domain containing 1A
2.45 0.0266 n-R5s71 nuclear encoded rRNA 5S 71 [Source:MGI Symbol;Acc:MGI:4421916]
2.41 0.0056 Gm6205 predicted gene 6205
2.38 0.0007 Dynap dynactin associated protein
2.31 0.0048 Slc18a2 solute carrier family 18 (vesicular monoamine), member 2
2.27 0.0023 Gm4541 Predicted gene 4541
2.25 0.0025 Txndc2 Thioredoxin domain containing 2
2.2 0.0021 Wee2 WEE1 homolog 2
2.19 0.0004 Nlrp9c NLR family, pyrin domain containing 9C
2.18 0.165 Khdc1c KH domain containing 1C
2.16 0.0003 Padi6 peptidyl arginine deiminase, type VI
2.15 8.81E-05 Gm1965 predicted gene 1965
2.14 0.005 Obox1 Oocyte specific homeobox 1
2.14 0.007 Tcl1b1 T cell leukemia/lymphoma 1B, 1
2.12 0.0002 Tcl1b3 T cell leukemia/lymphoma 1B, 3
2.12 0.0036 Gm6900 Predicted gene 6900 [Source:MGI Symbol;Acc:MGI:3645052]
2.11 0.0003 Fbxw19 F-box and WD-40 domain protein 19
2.08 0.0082 Fbxw15 F-box and WD-40 domain protein 15
2.07 0.0193 Ighv1–62-1 Immunoglobulin heavy variable 1–62-1
2.05 0.0025 Fbxw18 F-box and WD-40 domain protein 18
2.05 0.0084 Mir1901 microRNA 1901
2.02 0.0003 Zp3 zona pellucida glycoprotein 3
2.31 0.0053 Oas1e 2–5 oligoadenylate synthetase 1E
  1. Genes were significantly downregulated in Cy-injected mice when they displayed > 2.0-fold differences compared to the control (p < 0.05)