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Table 2 Biochemical parameters of serum and liver in the experimental groups

From: N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test

Groups Groups (Mean ± SD)
FPG (mg/dl) Plasma ALT (IU/L) Plasma AST (IU/L) Liver ALT (IU/L) Liver AST (IU/L) Liver MDA
(μmol/L)
Control 113.9 ±16.98 44.26 ±10.33 153.8 ± 42.11 173,700±45,540 91,180 ± 15,490 8.72 ± 1.46
APAP 95.10 ± 28.76 59.63 ± 15.56 158.8 ± 28.06 167,200± 50,750 92,420 ± 12,430 8.45 ± 2.39
NAC 104.0 ± 29.85 50.62 ± 3.765 137.7 ± 25.91 146,300± 30,530 87,420 ± 16,930 9.44 ± 0.99
AN 200 84.87 ± 36.98 57.30 ± 6.715 163.4 ± 11.25 181,200± 37,140 110,600 ± 16,930 6.91 ± 1.06
AN 400 101.2 ± 31.83 54.92 ± 11.18 171.4 ± 22.01 174,000± 35,010 97,150 ± 13,560 8.30 ± 3.13
AN 600 102.4 ± 38.89 60.37 ± 7.842 153.1 ± 25.58 162,900± 33,460 97,950 ± 20,470 9.81 ± 3.17
  1. The serum and liver level of liver enzyme activity and lipid peroxidation in control saline group (control) acetaminophen (APAP), N-acetylcysteine (NAC) and acetaminophen (300 mg/kg) combination with the various dosage of 200–600 mg/kg of NAC (AN 200, AN 400, AN 600) in rats. There were 8 Sprague-Dawley rats in each group. The data have been mentioned by mean± standard deviation. Each data in the all groups were analyzed through the one-way ANOVA. There were no significant differences