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Table 4 Mean salicylic acid pharmacokinetic parameters after oral doses of 2-hydroxybenzylamine

From: Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial

Parameter2-Hydroxybenzylamine acetate dose
500 mg (n = 6)750 mg (n = 5–6)
Day 1 (first dose)Day 15 (last dose)Day 1 (first dose)Day 15 (last dose)
Tmax (h)5.00 ± 1.103.50 ± 1.224.67 ± 1.033.20 ± 1.79
Cmax (ng/mL)7635 ± 211211,382 ± 411812,092 ± 261912,768 ± 3703
AUC0–8h (h·ng/mL)42,458 ± 12,07075,288 ± 28,09565,935 ± 13,77581,826 ± 28,120
AUC (h·ng/mL) 123,075 ± 55,044 117,842 ± 41,615
  1. Cmax, maximum observed plasma concentration; Tmax, time to reach Cmax; AUC, area under the concentration-time curve from zero to infinity; AUC0–8, area under the dosing interval curve.