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Fig. 7 | BMC Pharmacology and Toxicology

Fig. 7

From: Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study

Fig. 7

Immunohistochemical examination of TGF-β1. a. A kidney from the control group showing no expression of TGF-β in renal tissues. b. A kidney from the hyperuricemic group, showing a prominent expression of TGF-β1 in renal tubular tissue. c. A kidney from the ALP group, showing no marked expression of TGF-β1 in renal tissue. d. A kidney from the ZUR administered group, showing prominent expression of TGF-β1 in renal tubular tissue with moderate intensity. e. A kidney from the hyperuricemic group, treated with ALP shed absence of TGF-β1 immunoreactivity in tubular tissue. f. A kidney from the hyperuricemic group, treated with ZUR alone, showing a prominent moderate intensity of TGF-β1 in renal tissue. g. A kidney from the hyperuricemic group, treated with ZUR and ALP, showing glomerular and tubular tissue with no TGF-β1 expression. H&E. Scale bar = 50 μm

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