Fig. 2

Immunohistochemical detection and the protein expression of HMGB-1 (a)Normal group (b) Normal +Cs-A group (c) DM group and (d) DM + Cs-A group. Original magnification was 400X. Semiquantitative analyses of HMGB-1 levels were shown in (e). Data are mean ± SD, **p < 0.01 vs. Normal group and Normal +Cs-A group, and ※※P < 0.01 vs. DM group. (f) The expression HMGB-1 protein in Normal, Normal+Cs-A, DM and DM + Cs-A group respectively. (g) Mean ± SD of HMGB-1 protein level normalized to β-actin (internal control) were calculated. **p < 0.01 vs. Normal group and Normal +Cs-A group, and ※※p < 0.01 vs. DM group