| Younger adults (19–65) (n = 111,463) | Older adults (>  65) (n = 69,914) | OR older adults (>  65) vs. younger adults (19–65) [+/− adj. CI] | Patients aged 66–75 (n = 37,370) | OR patients aged 66–75 vs. younger adults [+/− adj. CI] | Patients aged 76–85 (n = 24,149) | OR patients aged 76–85 vs. younger adults [+/− adj. CI] | Patients aged ≥86 (n = 5649) | OR patients aged ≥86 vs. younger adults [+/− adj. CI] |
---|---|---|---|---|---|---|---|---|---|
Demographic parameters | |||||||||
 mean age (+/− SD) [years]b | 46.4 (+/−  12.8) | 75.4 (+/−7.2) | – | 70.5 (+/−  2.8) | – | 79.7 (+/−  2.7) | – | 89.1 (+/−  2.9) | – |
 median, [IQR] [years]b | 48 [37–57] | 75 [70–80] | – | 70 [68–73] | – | 79 [77–82] | – | 88 [87–91] | – |
 female | 60.3% (67,249) | 55.9% (39,065) | 0.8 [0.8–0.9]a | 52.8% (19,731) | 0.7 [0.7–0.8]a | 58.2% (14,049) | 0.9 [0.9–0.9]a | 68.3% (3861) | 1.4 [1.3–1.5]a |
 male | 38.4% (42,824) | 43.2% (30,230) |  | 46.4% (17,355) |  | 41.0% (9907) |  | 30.9% (1744) |  |
 unknown | 1.2% (1390) | 0.9% (619) |  | 0.8% (284) |  | 0.8% (193) |  | 0.8% (44) |  |
Reported patients’ history | |||||||||
 hypertensionc | 9.2% (10,302) | 24.5% (17,105) | 3.2 [3.1–3.3]a | 22.8% (8538) | 2.9 [2.8–3.1]a | 27.5% (6652) | 3.7 [3.5–3.9]a | 28.0% (1583) | 3.8 [3.5–4.2]a |
 cardiac disordersd | 7.3% (8180) | 24.5% (17,163) | 4.1 [3.9–4.3]a | 20.8% (7776) | 3.3 [3.2–3.5]a | 29.5% (7115) | 5.3 [5.0–5.6]a | 33.6% (1898) | 6.4 [5.8–7.0]a |
 diabetes e | 4.3% (4830) | 11.2% (7837) | 2.8 [2.6–3.0]a | 10.8% (4047) | 2.7 [2.5–2.9]a | 12.5% (3012) | 3.2 [2.9–3.4]a | 11.4% (643) | 2.8 [2.5–3.3]a |
 renal disordersf | 2.8% (3138) | 8.9% (6224) | 3.4 [3.2–3.6]a | 7.1% (2670) | 2.7 [2.4–2.9]a | 11.0% (2646) | 4.3 [3.9–4.6]a | 13.4% (759) | 5.4 [4.7–6.1]a |
 hepatic impairmentsg | 3.3% (3669) | 2.5% (1765) | 0.8 [0.7–0.8]a | 2.9% (1068) | 0.9 [0.8–1.0] | 2.4% (569) | 0.7 [0.6–0.8]a | 1.6% (90) | 0.5 [0.3–0.7]a |
Reported seriousness criteriah | |||||||||
 serious | 78.9% (87,954) | 83.9% (58,681) | 1.4 [1.3–1.5]a | 82.1% (30,669) | 1.2 [1.2–1.3]a | 84.8% (20,482) | 1.5 [1.4–1.6]a | 88.2% (4982) | 2.0 [1.8–2.3]a |
 death | 3.4% (3755) | 9.1% (6340) | 2.9 [2.7–3.0]a | 6.9% (2595) | 2.1 [2.0–2.3]a | 10.6% (2570) | 3.4 [3.2–3.7]a | 15.7% (886) | 5.3 [4.7–6.0]a |
 hospitalization | 32.7% (36,460) | 40.2% (28,094) | 1.4 [1.3–1.4]a | 37.8% (14,131) | 1.3 [1.2–1.3]a | 43.4% (10,490) | 1.6 [1.5–1.7]a | 46.1% (2603) | 1.8 [1.6–1.9]a |
 life-threatening | 8.2% (9171) | 11.9% (8332) | 1.5 [1.4–1.6]a | 11.3% (4223) | 1.4 [1.3–1.5]a | 13.1% (3172) | 1.7 [1.6–1.8]a | 14.6% (825) | 1.9 [1.7–2.1]a |
 disabling | 2.7% (3020) | 3.0% (2118) | 1.1 [1.0–1.2] | 3.2% (1179) | 1.2 [1.1–1.3]a | 3.0% (731) | 1.1 [1.0–1.3] | 2.7% (151) | 1.0 [0.8–1.3] |