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Table 2 Estimated effects of factors, F-ratios, and associated P-values for the studied responses Y1-Y3

From: Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity

Factor Y1 Y2 Y3
Estimated effect F-ratio P-Value Estimated effect F-ratio P-Value Estimated effect F-ratio P-Value
X1 21.415 6.68 0.0492a −1.67 6.08 0.0569 1.568 0.75 0.4262
X2 −45.985 30.80 0.0026a −1.825 7.26 0.0431a 1.638 0.82 0.4073
X3 714.135 2252.15 0.00001a 14.160 132.45 0.0001a 35.187 114.48 0.0001a
X1X1 −8.209 0.68 0.4472 3.333 16.76 0.0094a 0.067 0.00 0.9767
X1X2 −25.09 6.88 0.0470a −0.78 0.99 0.3645 3.455 2.73 0.1593
X1X3 7.375 0.38 0.5644 1.5 2.35 0.1856 −0.944 0.13 0.7328
X2X2 −13.884 1.94 0.2220 3.953 23.58 0.0047a 1.932 0.79 0.4154
X2X3 2.506 0.04 0.8423 0.113 0.01 0.9129 −4.363 2.79 0.1559
X3X3 266.368 293.08 0.00001a 7.115 31.27 0.0025a −9.092 7.15 0.0442a
R2 (%) 99.87 97.99 99.09
Adj. R2 (%) 99.64 94.38 97.47
SE of Est. 9.57 0.782 2.091
Mean AE 4.82 0.406 1.058
  1. Abbreviations: X1 Drug to phospholipid, X2 Surfactant concentration, X3 Coating solution concentration, Y1 Particle size (nm), Y2 Entrapment efficiency (%), Y3 Zeta potential (mV), X1X2, X1X3, and X2X3 are the interaction effects of the studied factors, X1X1, X2X2 and X3X3 are the quadratic effects of factors, SE Standard error, AE Absolute error
  2. Note: a indicates significant effect of this factor on the studied response