Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity

Table 2 Estimated effects of factors, F-ratios, and associated P-values for the studied responses Y₁-Y₃

Factor	Y₁			Y₂			Y₃
Factor	Estimated effect	F-ratio	P-Value	Estimated effect	F-ratio	P-Value	Estimated effect	F-ratio	P-Value
X₁	21.415	6.68	0.0492^a	−1.67	6.08	0.0569	1.568	0.75	0.4262
X₂	−45.985	30.80	0.0026^a	−1.825	7.26	0.0431^a	1.638	0.82	0.4073
X₃	714.135	2252.15	0.00001^a	14.160	132.45	0.0001^a	35.187	114.48	0.0001^a
X₁X₁	−8.209	0.68	0.4472	3.333	16.76	0.0094^a	0.067	0.00	0.9767
X₁X₂	−25.09	6.88	0.0470^a	−0.78	0.99	0.3645	3.455	2.73	0.1593
X₁X₃	7.375	0.38	0.5644	1.5	2.35	0.1856	−0.944	0.13	0.7328
X₂X₂	−13.884	1.94	0.2220	3.953	23.58	0.0047^a	1.932	0.79	0.4154
X₂X₃	2.506	0.04	0.8423	0.113	0.01	0.9129	−4.363	2.79	0.1559
X₃X₃	266.368	293.08	0.00001^a	7.115	31.27	0.0025^a	−9.092	7.15	0.0442^a
R² (%)	99.87			97.99			99.09
Adj. R² (%)	99.64			94.38			97.47
SE of Est.	9.57			0.782			2.091
Mean AE	4.82			0.406			1.058

Abbreviations: X₁ Drug to phospholipid, X₂ Surfactant concentration, X₃ Coating solution concentration, Y₁ Particle size (nm), Y₂ Entrapment efficiency (%), Y₃ Zeta potential (mV), X₁X₂, X₁X₃, and X₂X₃ are the interaction effects of the studied factors, X₁X_1, X₂X₂ and X₃X₃ are the quadratic effects of factors, SE Standard error, AE Absolute error
Note: ^a indicates significant effect of this factor on the studied response

ISSN: 2050-6511