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Table 2 Estimated effects of factors, F-ratios, and associated P-values for the studied responses Y1-Y3

From: Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity

FactorY1Y2Y3
Estimated effectF-ratioP-ValueEstimated effectF-ratioP-ValueEstimated effectF-ratioP-Value
X121.4156.680.0492a−1.676.080.05691.5680.750.4262
X2−45.98530.800.0026a−1.8257.260.0431a1.6380.820.4073
X3714.1352252.150.00001a14.160132.450.0001a35.187114.480.0001a
X1X1−8.2090.680.44723.33316.760.0094a0.0670.000.9767
X1X2−25.096.880.0470a−0.780.990.36453.4552.730.1593
X1X37.3750.380.56441.52.350.1856−0.9440.130.7328
X2X2−13.8841.940.22203.95323.580.0047a1.9320.790.4154
X2X32.5060.040.84230.1130.010.9129−4.3632.790.1559
X3X3266.368293.080.00001a7.11531.270.0025a−9.0927.150.0442a
R2 (%)99.8797.9999.09
Adj. R2 (%)99.6494.3897.47
SE of Est.9.570.7822.091
Mean AE4.820.4061.058
  1. Abbreviations: X1 Drug to phospholipid, X2 Surfactant concentration, X3 Coating solution concentration, Y1 Particle size (nm), Y2 Entrapment efficiency (%), Y3 Zeta potential (mV), X1X2, X1X3, and X2X3 are the interaction effects of the studied factors, X1X1, X2X2 and X3X3 are the quadratic effects of factors, SE Standard error, AE Absolute error
  2. Note: a indicates significant effect of this factor on the studied response