Development of rosuvastatin flexible lipid-based nanoparticles: promising nanocarriers for improving intestinal cells cytotoxicity

Table 3 The optimum levels and values, and desirability levels and values for the studied factors and responses

Factors	Low	High	Optimum level for each response			Optimum desirability level
Factors	Low	High	Y₁ = 99.12 nm	Y₂ = 95.99%	Y₃ = 28.85 mV	Optimum desirability level
X₁ (MR)	1.0	4.0	1.0	1.0	1.0	1.0
X₂ (%)	0.01	0.04	0.04	0.01	0.01	0.01
X₃ (%)	0.2	0.6	0.2	0.6	0.59	0.47
Responses	Goal		Optimum desirability
Responses	Goal		Predicted values	Observed values		Residual
Y₁ (nm)	Minimize		331.09	342.33		11.24
Y₂ (%)	Maximize		92.31	94.01		1.7
Y₃ (mV)	Maximize		19.39	21.22		1.83

Abbreviations: X₁ Drug to phospholipid, X₂ Surfactant concentration, X₃ Coating solution concentration, Y₁ Particle size, Y₂ Entrapment efficiency, Y₃ Zeta potential, MR Molar ratio

ISSN: 2050-6511