Fig. 2

The members of NF-κB family. The Rel homology domain is characteristic for all memb ers the NF-κB family, while the ankyrin repeats only for the NF-κB inhibitors and the NF-κB precursors of p50 and p52 subunits (p100, p105). The transactivation domain is a C-terminal non-homologous domain that is important for NF-κB-mediated gene transactivation. For activation of transactivation domain, RelB requires an amino-terminal leucine zipper region