Table 2 Male and female mice fed emodin for 12-weeks do not show pertubations in CBC counts. White blood cells (WBC), lymphocytes (LYM), monocytes (MON), neutrophils (NEU), neutrophil:lymphoctye ratio (NLR), red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), and platelets (PLT) were measured using a VetScan HMT (Abaxis, Union City, CA). n = 5/group
From: Safety of natural anthraquinone emodin: an assessment in mice
Group | WBC (10^9/l) | LYM (10^9/l) | MON (10^9/l) | NEU (10^9/l) | NLR | RBC (10^12/l) | HGB (g/dl) | HCT (%) | PLT (10^9/l) |
|---|---|---|---|---|---|---|---|---|---|
Control (AIN) | 5.39 ± 0.63 | 4.03 ± 0.38 | 0.21 ± 0.06 | 1.15 ± 0.31 | 0.27 ± 0.06 | 10.41 ± 0.54 | 15.97 ± 0.15 | 42.06 ± 1.86 | 717.78 ± 62.73 |
Low Emodin (20 mg/kg) | 4.99 ± 0.32 | 3.97 ± 0.26 | 0.17 ± 0.04 | 0.85 ± 0.10 | 0.21 ± 0.02 | 10.82 ± 0.10 | 16.39 ± 0.15 | 42.88 ± 0.43 | 716.90 ± 22.33 |
Medium Emodin (40 mg/kg) | 5.30 ± 0.43 | 4.31 ± 0.29 | 0.14 ± 0.04 | 0.85 ± 0.16 | 0.19 ± 0.02 | 10.49 ± 0.14 | 16.39 ± 0.25 | 41.86 ± 0.59 | 680.20 ± 32.56 |
High Emodin (80 mg/kg) | 5.58 ± 0.38 | 4.48 ± 0.31 | 0.18 ± 0.04 | 0.91 ± 0.12 | 0.21 ± 0.03 | 10.23 ± 0.17 | 16.03 ± 0.25 | 40.32 ± 0.67 | 693.60 ± 26.30 |