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Table 2 Cell viability (%) of ibuprofen derivatives (4a-n) at 50 μg/ml

From: New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile

Comp.

24 h

48 h

72 h

Comp.

24 h

48 h

72 h

4a

2.41 ± 0.40

1.51 ± 0.18

0.45 ± 0.07

4 h

5.77 ± 0.25

3.53 ± 0.20

3.01 ± 0.32

4b

2.06 ± 0.16

1.64 ± 0.33

0.34 ± 0.09

4i

1.40 ± 0.26

1.87 ± 0.22

1.28 ± 0.21

4c

5.43 ± 0.29

2.78 ± 0.12

3.42 ± 0.23

4j

4.43 ± 0.14

2.96 ± 0.12

2.65 ± 0.08

4d

5.85 ± 0.38

3.32 ± 0.12

3.63 ± 0.08

4 k

2.48 ± 0.67

1.17 ± 0.11

1.51 ± 0.38

4e

6.27 ± 0.35

2.58 ± 0.11

1.14 ± 0.08

4 l

15.56 ± 1.56

3.71 ± 0.10

3.27 ± 0.35

4f

2.02 ± 0.35

1.14 ± 0.24

1.09 ± 0.19

4 m

59.89 ± 1.31

56.18 ± 0.88

53.12 ± 1.65

4 g

7.36 ± 0.52

3.23 ± 0.18

3.01 ± 0.53

4n

64.25 ± 1.06

54.87 ± 0.89

52.37 ± 1.84

Ibuprofen

91.78 ± 2.41

90.46 ± 1.11

87.70 ± 0.29

DMSO 5%

36.43 ± 1.45

14.40 ± 1.00

6.95 ± 0.38