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Table 4 Uni- and multivariate linear regression analysis of variables associated with linezolid Cmin at standard dose of 600 mg every 12 h

From: Proposal of initial and maintenance dosing regimens with linezolid for renal impairment patients

Variables Univariate analysis Multivariate analysisa
Unstandardized β coefficient (95%CI) P-value Unstandardized β coefficient (95%CI) P-value
Male −2.81 (−6.95 to 1.34) 0.18   
Age (years) (per 1-year increment) 0.285 (0.173 to 0.396) < 0.0001   
Height (m) (per 1-m increment) −33.71 (−51.35 to −16.07) 0.0003   
Body weight (kg) (per 1-kg increment) −0.294 (−0.427 to −0.160) < 0.0001 −0.208 (−0.335 to 0.081) 0.0016
CLCRC-G ≤ 60 mL/min 11.37 (7.397 to 15.345) < 0.0001 4.777 (2.793 to 6.760) < 0.0001
Total bilirubin > 1.2 mg/dL 1.111(−2.960–5.199) 0.59   
Co-treatment
 Omeprazole −1.097 (−7.273 to 5.079) 0.73   
 Amiodarone 4.676 (−1.243 to 10.595) 0.12   
 Amlodipine 1.037 (−13.885 to 15.960) 0.89   
 Rifampicin 2.236 (−5.028 to 9.501) 0.54   
 Dexamethasone 0.426 (−14.450 to 15.350) 0.96   
  1. aR2 = 0.301
  2. Abbreviation: CLCRC-G creatinine clearance calculated using the Cockcroft-Gault formula